A chemical chaperone induces inhomogeneous conformational changes in flexible proteins-Reference-Cited by-同舟云学术

A chemical chaperone induces inhomogeneous conformational changes in flexible proteins

Published:2016 Issue:30 Volume:18 Page:20410-20421
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Hamdane Djemel¹²³⁴⁵,Velours Christophe⁶⁷⁸⁹¹⁰,Cornu David¹¹⁸¹²¹³⁵,Nicaise Magali⁶⁷⁸⁹¹⁰,Lombard Murielle¹²³⁴⁵,Fontecave Marc¹²³⁴⁵

Affiliation:

1. Laboratoire de Chimie des Processus Biologiques

2. CNRS-UMR 8229

3. Collège De France

4. 75231 Paris Cedex 05

5. France

6. Macromolecular Interaction Platform of I2BC

7. UMR 9198

8. Centre de Recherche de Gif

9. Centre National de la Recherche Scientifique

10. 91191 Gif Sur Yvette

11. CNRS

12. SICaPS

13. F-91198 Gif-sur-Yvette Cedex

Abstract

Organic osmolytes are major cellular compounds that favor protein's compaction and stabilization of the native state. Here, we have examined the chaperone effect of the naturally occurring trimethylamine N-oxide (TMAO) osmolyte on a flexible protein.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C6CP03635J

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4. Modulation of Functionally Significant Conformational Equilibria in Adenylate Kinase by High Concentrations of Trimethylamine Oxide Attributed to Volume Exclusion

5. Effect of Osmolytes on Protein Dynamics in the Lactate Dehydrogenase-Catalyzed Reaction

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