More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH-Reference-Cited by-同舟云学术

More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH

Published:2016 Issue:10 Volume:12 Page:2992-3004
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Ulrich Veronika¹²³⁴,Peschke Madeleine¹²³⁴,Brieke Clara¹²³⁴,Cryle Max J.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biomolecular Mechanisms

2. Max Planck Institute for Medical Research

3. 69121 Heidelberg

4. Germany

5. EMBL Australia

Abstract

Cytochrome P450 StaH catalyses the first cyclisation reaction in the biosynthesis of the glycopeptide antibiotic A47934 via recruitment to the NRPS machinery through interaction with the X-domain.

Funder

Deutsche Forschungsgemeinschaft

Monash University

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MB/C6MB00373G

Reference51 articles.

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3. Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics

4. Glycopeptide antibiotic biosynthesis

5. Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines

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