Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression-Reference-Cited by-同舟云学术

Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression

Published:2016 Issue:6 Volume:8 Page:720-728
ISSN:1757-9694
Container-title:Integrative Biology
language:en
Short-container-title:Integr. Biol.

Author:

Caliari Steven R.¹²³,Perepelyuk Maryna⁴⁵²³,Soulas Elizabeth M.¹²³,Lee Gi Yun¹²³,Wells Rebecca G.⁴⁵²³,Burdick Jason A.¹²³

Affiliation:

1. Department of Bioengineering, University of Pennsylvania

2. Philadelphia

3. USA

4. Department of Medicine

5. University of Pennsylvania

Abstract

The extracellular matrix (ECM) presents an evolving set of mechanical cues to resident cells. Here we developed a hydrogel combining stable and hydrolytically degradable crosslinks to model fibrosis resolution.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://pubs.rsc.org/en/content/articlepdf/2016/IB/C6IB00027D

Reference29 articles.

1. Cellular and molecular mechanisms of fibrosis

2. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

3. Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

4. Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

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