Sophora interrupta Bedd. root-derived flavonoids as prominent antiviral agents against Newcastle disease virus

Author:

Bhuvaneswar Cherukupalle12345,Rammohan Aluru67234ORCID,Bhaskar Baki Vijaya891011,Babu Pappithi Ramesh1234,Naveen Gujjar12134,Gunasekar Duvvuru67234,Madhuri Subbiah12134ORCID,Reddanna Pallu1415164,Rajendra Wudayagiri1234ORCID

Affiliation:

1. Department of Zoology

2. Sri Venkateswara University

3. Tirupati-517502

4. India

5. Department of Microbiology

6. Natural Products Division

7. Department of Chemistry

8. Department of Pathophysiology

9. Shantou University Medical College

10. Shantou

11. China-515031

12. National Institute of Animal Biotechnology (NIAB)

13. Hyderabad-500049

14. School of Life Sciences

15. University of Hyderabad (UOH)

16. Hyderabad-500046

Abstract

The two flavonoids, maackiain and echinoisoflavanone from roots of Sophora interrupta Bedd. have shown prominent in vitro antiviral activities by preventing viral replication and transcription than Ribavirin against NDV in DF-1 cells.

Funder

Council of Scientific and Industrial Research, India

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference43 articles.

1. D. J.Alexander and D. A.Senne , Newcastle disease, other avian paramyxoviruses, and pneumovirus infections , in Diseases of Poultry , ed. Y. M. Saif , A. M. Fadly , J. R. Glisson , L. R. McDougald , L. K. Nolan and D. E. Swayne , Blackwell Publishing , Lova, USA , 12th edn, 2008 , pp. 75–115

2. L.Dufour-Zavala , A laboratory manual for the isolation, identification, and characterization of avian pathogens , American Association of Avian Pathologists , Jacksonville, Fl., USA , 5th edn, 2008 , pp. 135–141

3. D. J.Alexander and R. E.Gough , Newcastle disease, other avian Paramyxoviruses, and Pneumovirus infections , in Disease of Poultry , ed. Y. M. Saif , H. J. Barnes , J. R. Glisson , A. M. Fadly , L. R. McDougald , L. K. Nolan , D. E. Swayne , Iowa State Press , Ames, IA 1A , 11th edn, 2003 , pp. 63–99

4. In vitro efficacy of ribavirin against canine distemper virus

5. Biochemistry and clinical applications of ribavirin

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