Controlling lamellarity and physicochemical properties of liposomes prepared using a microfluidic device

Author:

Matsuura-Sawada Yuka12,Maeki Masatoshi345ORCID,Uno Shuya1ORCID,Wada Koichi2,Tokeshi Manabu3ORCID

Affiliation:

1. Graduate School of Chemical Sciences and Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo, 060-8628, Japan

2. Department of Chemistry, Manufacturing and Control, Kobe Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd., 6-7-5, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

3. Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan

4. JST PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan

5. Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki 305-0801, Japan

Abstract

The function of liposomal drugs and cosmetics is not only controlled by the lipid composition/formulation, but also by the liposome size and internal structure/properties (uni- and multi-lamellae) and membrane rigid/fluidic properties.

Funder

Hokkaido University

Japan Agency for Medical Research and Development

Precursory Research for Embryonic Science and Technology

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science

Core Research for Evolutional Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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