Development of potential therapeutics for pain treatment by inducing Sigma 1 receptor antagonism – in silico approach
Author:
Affiliation:
1. Department for Cardiac Surgery
2. Clinic for Anaesthesiology and Intensive Therapy
3. Clinical Center Niš
4. Niš
5. Serbia
6. Faculty of Medicine
7. Department of Chemistry
8. Medical School of Niš
9. University of Niš
10. 18000 Niš
Abstract
QSAR modeling with computer-aided drug design were used for the in silico development of novel therapeutics for pain treatment.
Funder
Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ00883H
Reference46 articles.
1. Sigma receptors: biology and therapeutic potential
2. Understanding the Molecular Mechanism of Sigma-1 Receptors: Towards A Hypothesis that Sigma-1 Receptors are Intracellular Amplifiers for Signal Transduction
3. Immunocytochemical localization of the sigma1 receptor in the adult rat central nervous system
4. Sigma-1 Receptor Expression in Sensory Neurons and the Effect of Painful Peripheral Nerve Injury
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