Quaternary tannic acid with improved leachability and biocompatibility for antibacterial medical thermoplastic polyurethane catheters

Author:

Wang Yue12345,Liu Shuaizhen12345,Ding Kaidi678,Zhang Yaocheng12345,Ding Xuejia12345ORCID,Mi Jianguo12345

Affiliation:

1. Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

2. Ministry of Education

3. Beijing Laboratory of Biomedical Materials

4. Beijing University of Chemical Technology

5. Beijing

6. Worcester Polytechnic Institute

7. Worcester

8. USA

Abstract

A quaternary tannic acid (QTA) was synthesized and blended into TPU using the melt extrusion process. The QTA–TPU showed improved leachability and biocompatibility and good antibacterial activity under static and flow conditions and in vivo.

Funder

National Key Research and Development Program of China

Jiangsu Provincial Key Research and Development Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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