A cationic amphiphilic peptide chaperone rescues Aβ<sub>42</sub> aggregation and cytotoxicity-Reference-Cited by-同舟云学术

A cationic amphiphilic peptide chaperone rescues Aβ₄₂ aggregation and cytotoxicity

Published:2023 Issue:2 Volume:14 Page:332-340
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Puneeth Kumar DRGKoppalu R.¹,Reja Rahi M.¹,Senapati Dillip K.²,Singh Manjeet¹,Nalawade Sachin A.¹,George Gijo²^ORCID,Kaul Grace³⁴^ORCID,Akhir Abdul³,Chopra Sidharth³⁴^ORCID,Raghothama Srinivasarao²,Gopi Hosahudya N.¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pashan, Pune-411008, India

2. NMR Research Centre, Indian Institute of Science, Bangalore-560012, India

3. Division of Microbiology and Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Janakipuram Extension, Lucknow-226031, Uttar Pradesh, India

4. AcSIR: Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

Abstract

A cationic amphiphilic peptide effectively prevents the aggregation of soluble Aβ42 and also disintegrates matured fibrils into soluble precursors. In addition, the peptide also rescues cells from the toxicity of Aβ42.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00414C

Reference50 articles.

1. Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

2. Protein Misfolding, Functional Amyloid, and Human Disease

3. Folding proteins in fatal ways

4. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

5. Alzheimer's Disease: From Pathology to Therapeutic Approaches

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Proteolytically Stable ααγ-Hybrid Peptides Inhibit the Aggregation and Cytotoxicity of Aβ₄₂;ACS Chemical Neuroscience;2023-09-01