Characterization of a functional C3A liver spheroid model-Reference-Cited by-同舟云学术

Characterization of a functional C3A liver spheroid model

Published:2016 Issue:4 Volume:5 Page:1053-1065
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Gaskell Harriet¹²³⁴⁵,Sharma Parveen¹²³⁴,Colley Helen E.⁶⁷⁸⁹⁴,Murdoch Craig⁶⁷⁸⁹⁴,Williams Dominic P.⁵⁴,Webb Steven D.¹⁰¹¹¹²⁴

Affiliation:

1. MRC Centre for Drug Safety Science

2. Department of Molecular and Clinical Pharmacology

3. University of Liverpool

4. UK

5. AstraZeneca

6. Academic Unit of Oral and Maxillofacial Pathology

7. School of Clinical Dentistry

8. University of Sheffield

9. Sheffield

10. Department of Mathematical Sciences

11. Liverpool John Moores University

12. Liverpool

Abstract

We have developed a method for creating C3A liver spheroids and demonstrated cellular polarisation, zonation as well as increased liver-specific functionality and more predictive toxicological response compared to standard 2D liver models.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TX/C6TX00101G

Reference50 articles.

1. Incidence of Adverse Drug Reactions in Hospitalized Patients

2. Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

3. Drug-induced liver injury in 2007

4. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

5. Microengineered Liver Tissues for Drug Testing

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