Applying molecular networking for targeted isolation of depsipeptides

Author:

Lin Xiao12345ORCID,Chai Ling6784,Zhu Hong Rui910111213,Zhou Yongjun910111213,Shen Yaoyao910111213,Chen Kai Hao910111213,Sun Fan910111213,Liu Bu Ming6784,Xu Shi Hai514154,Lin Hou Wen910111213ORCID

Affiliation:

1. Institute of Marine Drugs

2. Guangxi University of Chinese Medicine

3. Nanning 530200

4. P. R. China

5. College of Chemistry and Materials

6. Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards

7. Guangxi Institute of Traditional Medical and Pharmaceutical Sciences

8. Nanning

9. Research Center for Marine Drugs

10. State Key Laboratory of Oncogenes and Related Genes

11. Department of Pharmacy

12. Ren Ji Hospital

13. School of Medicine

14. Jinan University

15. Guangzhou 510632

Abstract

LC-HRMS/MS molecular networking enabled the targeted isolation of three new neoantimycin analogs (1, 3, 5) and two known ones (2, 4) from the culture broth of Streptomyces conglobatus RJ8.

Funder

National Natural Science Foundation of China

Guangzhou Science and Technology Program key projects

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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