Applying molecular networking for targeted isolation of depsipeptides-Reference-Cited by-同舟云学术

Applying molecular networking for targeted isolation of depsipeptides

Published:2021 Issue:5 Volume:11 Page:2774-2782
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lin Xiao¹²³⁴⁵^ORCID,Chai Ling⁶⁷⁸⁴,Zhu Hong Rui⁹¹⁰¹¹¹²¹³,Zhou Yongjun⁹¹⁰¹¹¹²¹³,Shen Yaoyao⁹¹⁰¹¹¹²¹³,Chen Kai Hao⁹¹⁰¹¹¹²¹³,Sun Fan⁹¹⁰¹¹¹²¹³,Liu Bu Ming⁶⁷⁸⁴,Xu Shi Hai⁵¹⁴¹⁵⁴,Lin Hou Wen⁹¹⁰¹¹¹²¹³^ORCID

Affiliation:

1. Institute of Marine Drugs

2. Guangxi University of Chinese Medicine

3. Nanning 530200

4. P. R. China

5. College of Chemistry and Materials

6. Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards

7. Guangxi Institute of Traditional Medical and Pharmaceutical Sciences

8. Nanning

9. Research Center for Marine Drugs

10. State Key Laboratory of Oncogenes and Related Genes

11. Department of Pharmacy

12. Ren Ji Hospital

13. School of Medicine

14. Jinan University

15. Guangzhou 510632

Abstract

LC-HRMS/MS molecular networking enabled the targeted isolation of three new neoantimycin analogs (1, 3, 5) and two known ones (2, 4) from the culture broth of Streptomyces conglobatus RJ8.

Funder

National Natural Science Foundation of China

Guangzhou Science and Technology Program key projects

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA09388B

Reference20 articles.

1. Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities

2. New antibiotics produced by streptoverticillium orinoci, n. sp.

3. Rare Streptomyces N-Formyl Amino-salicylamides Inhibit Oncogenic K-Ras

4. Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library

5. Directed Accumulation of Anticancer Depsipeptides by Characterization of Neoantimycins Biosynthetic Pathway and an NADPH-Dependent Reductase

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