Effect of new carbonyl cyanide aromatic hydrazones on biofilm inhibition against methicillin resistant Staphylococcus aureus
Author:
Affiliation:
1. School of Medicine
2. Anhui University of Science and Technology
3. Huainan 232001
4. China
5. Anhui Prevention and Treatment Center for Occupational Disease
6. School of Pharmacy
7. Anhui Medical University
8. Hefei 230032
Abstract
2e and 2j with strong p-NO2 and p-CF3 at phenyl ring had the lowest MICs against S. aureus and MRSA. 2e displayed unaided or synergistic efficacy against MRSA, especially combined with ofloxacin. EM revealed that 2e destroys biofilms and cell membranes.
Funder
Natural Science Foundation of Anhui Province
Anhui Department of Education
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03124K
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