Effect of new carbonyl cyanide aromatic hydrazones on biofilm inhibition against methicillin resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Effect of new carbonyl cyanide aromatic hydrazones on biofilm inhibition against methicillin resistant Staphylococcus aureus

Published:2020 Issue:30 Volume:10 Page:17854-17861
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lu Xueer¹²³⁴⁵,Zhang Ziwen⁶⁷⁸⁴,Xu Yingying⁶⁷⁸⁴,Lu Jun¹²³⁴,Tang Wenjian⁶⁷⁸⁴^ORCID,Zhang Jing¹²³⁴⁵^ORCID

Affiliation:

1. School of Medicine

2. Anhui University of Science and Technology

3. Huainan 232001

4. China

5. Anhui Prevention and Treatment Center for Occupational Disease

6. School of Pharmacy

7. Anhui Medical University

8. Hefei 230032

Abstract

2e and 2j with strong p-NO₂ and p-CF₃ at phenyl ring had the lowest MICs against S. aureus and MRSA. 2e displayed unaided or synergistic efficacy against MRSA, especially combined with ofloxacin. EM revealed that 2e destroys biofilms and cell membranes.

Funder

Natural Science Foundation of Anhui Province

Anhui Department of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03124K

Reference27 articles.

1. Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

2. ESKAPEing the labyrinth of antibacterial discovery