A pyridinium-based strategy for lysine-selective protein modification and chemoproteomic profiling in live cells-Reference-Cited by-同舟云学术

A pyridinium-based strategy for lysine-selective protein modification and chemoproteomic profiling in live cells

Published:2024 Issue:14 Volume:15 Page:5340-5348
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wan Chuan¹,Yang Dongyan²,Song Chunli³,Liang Mingchan³,An Yuhao³^ORCID,Lian Chenshan³,Dai Chuan³,Ye Yuxin³,Yin Feng³,Wang Rui³^ORCID,Li Zigang⁴³^ORCID

Affiliation:

1. College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, 518118, P. R. China

2. College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, P. R. China

3. Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, P. R. China

4. State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China

Abstract

The utilization of the cationic-pyridinium activated ester strategy facilitates the chemoselective labeling of lysine residues within proteins, enabling activity-based protein profiling (ABPP) both in vitro and in live cells.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Basic and Applied Basic Research Foundation of Guangdong Province

Shenzhen-Hong Kong Institute of Brain Science

Shenzhen Science and Technology Innovation Program

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05766F

Reference59 articles.

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5. Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID

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