Role of aptamer technology in extracellular vesicle biology and therapeutic applications

Author:

Chowdhury Rocky1ORCID,Eslami Sadegh2ORCID,Pham Cuong Viet3,Rai Alin24ORCID,Lin Jia5,Hou Yingchu6ORCID,Greening David W.24ORCID,Duan Wei1ORCID

Affiliation:

1. School of Medicine, Deakin University, and IMPACT Strategic Research Centre, Waurn Ponds, VIC, 3216, Australia

2. Molecular Proteomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

3. Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia

4. Department of Cardiovascular Research, Translation and Implementation, and La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia

5. Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China

6. Laboratory of Tumor Molecular and Cellular Biology College of Life Sciences, Shaanxi Normal University 620 West Chang'an Avenue, Xi'an, Shaanxi, 710119, China

Abstract

This review summarizes how aptamers (chemical antibodies) at the molecular level propel the advancement of the application of nano-scaled extracellular vesicles in nanotechnology and medicine, highlighting the latest developments since 2023.

Funder

National Health and Medical Research Council

National Heart Foundation of Australia

Publisher

Royal Society of Chemistry (RSC)

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