Pd-catalysed intramolecular transformations of indolylbenzenesulfonamides: ortho-sulfonamido-bi(hetero)aryls via C2-arylation and polycyclic sultams via C3 arylation-Reference-Cited by-同舟云学术

Pd-catalysed intramolecular transformations of indolylbenzenesulfonamides: ortho-sulfonamido-bi(hetero)aryls via C2-arylation and polycyclic sultams via C3 arylation

Published:2022 Issue:46 Volume:20 Page:9148-9160
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sunke Rajnikanth¹,Ahmed Khan Shabbir¹,Kumara Swamy K. C.¹^ORCID

Affiliation:

1. School of Chemistry, University of Hyderabad, Hyderabad 500 046, Telangana, India

Abstract

Indolyl substituted iodo-sulfonamides deliver 2-aryl(sulfonamido)indoles in the presence of Pd(OAc)2/Ph3P/Et3N; the same reactants, using Pd(OAc)2/Ph3P/K2CO3, afford indole-fused sultams.

Funder

University Grants Commission

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01610A

Reference50 articles.

1. A Highly Potent, Orally Active Imidazo[4,5-b]pyridine Biphenyl Acylsulfonamide (MK-996; L-159,282): A New AT1-Selective Angiotensin II Receptor Antagonist

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3. Neurological perspectives on voltage-gated sodium channels

4. Biphenylsulfonamide Endothelin Antagonists: Structure−Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2‘-Amino-N- (3,4-dimethyl-5-isoxazolyl)-4‘-(2-methylpropyl)[1,1‘-biphenyl]-2-sulfonamide (BMS-187308)

5. The Challenge of Atropisomerism in Drug Discovery