Gadolinium complexes of diethylenetriamine-N-oxide pentaacetic acid-bisamide: a new class of highly stable MRI contrast agents with a hydration number of 3-Reference-Cited by-同舟云学术

Gadolinium complexes of diethylenetriamine-N-oxide pentaacetic acid-bisamide: a new class of highly stable MRI contrast agents with a hydration number of 3

Published:2019 Issue:5 Volume:48 Page:1693-1699
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Zhang BeiBei¹²³⁴⁵,Cheng Likun¹²³⁴⁵,Duan Bing⁶⁴⁵,Tang Weijun⁷⁸⁴⁵,Yuan Yuan⁶⁴⁵^ORCID,Ding Yun¹²³⁴⁵,Hu Aiguo¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory of Advanced Polymeric Materials

2. School of Materials Science and Engineering

3. East China University of Science and Technology

4. Shanghai

5. China

6. The State Key Laboratory of Bioreactor Engineering East China University of Science and Technology

7. Department of Radiology

8. Huashan Hospital Affiliated to Fudan University

Abstract

Diethylenetriamine-N-oxide pentaacetic acid-bisamide-based Gd(iii) complexes with 3 coordinated water molecules have been synthesized to achieve high stability and over three times of the relaxivities of commercial MRI contrast agents.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C8DT04478C

Reference42 articles.

1. High-Relaxivity MRI Contrast Agents: Where Coordination Chemistry Meets Medical Imaging

2. The relationship between thermodynamics and the toxicity of gadolinium complexes

3. Next Generation, High Relaxivity Gadolinium MRI Agents