Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing-Reference-Cited by-同舟云学术

Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing

Published:2024 Issue: Volume: Page:
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Silva-Brenes Diana V.¹²^ORCID,Agrawal Shailesh¹^ORCID,López-Mejías Vilmalí¹³^ORCID,Duconge Jorge⁴,Vlaar Cornelis P.⁴^ORCID,Monbaliu Jean-Christophe M.²⁵^ORCID,Stelzer Torsten¹⁴^ORCID

Affiliation:

1. Crystallization Design Institute, Molecular Sciences Research Center, University of Puerto Rico, San Juan, Puerto Rico 00926, USA

2. Center for Integrated Technology and Organic Synthesis, MolSys Research Unit, University of Liège, B-4000 Liège Sart Tilman, Belgium

3. Department of Chemistry, University of Puerto Rico, Río Piedras Campus, San Juan, Puerto Rico 00931, USA

4. Department of Pharmaceutical Sciences, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico 00936, USA

5. WEL Research Institute, Avenue Pasteur 6, B-1300 Wavre, Belgium

Abstract

This study reports efforts toward the integrated advanced manufacturing of the anti-narcoleptic drug modafinil via flow chemistry and continuous crystallization.

Funder

National Aeronautics and Space Administration

Fonds De La Recherche Scientifique - FNRS

Université de Liège

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RE/D4RE00273C

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