Preparation and solid-state characterization of dapsone pharmaceutical cocrystals through the supramolecular synthon strategy

Author:

Zhao Chenyang1,Li Wanya1,Li Zhonghua1,Hu Weiguo12,Zhang Suoqing12,Wu Songgu1ORCID

Affiliation:

1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China

2. North China Pharmaceutical Group Co., Ltd., Shijiazhuang, P. R. China

Abstract

Based on the design concept of supramolecular synthons, “–NH2⋯Npyridine” was used to prepare cocrystals of DAP: (1 : 1) and (2 : 1) DAP-PYR, which could be transformed into each other by mechanochemistry.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

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