Turning cationic antimicrobial peptide KR-12 into self-assembled nanobiotics with potent bacterial killing and LPS neutralizing activities-Reference-Cited by-同舟云学术

Turning cationic antimicrobial peptide KR-12 into self-assembled nanobiotics with potent bacterial killing and LPS neutralizing activities

Published:2024 Issue:2 Volume:16 Page:887-902
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Lei Ruyi¹,Yang Chujun¹²^ORCID,Sun Yaqi³,Li Dejian¹,Hao Liman⁴,Li Yang⁴,Wu Shuijing⁴,Li Hui⁴,Lan Chao¹,Fang Xiangming⁴

Affiliation:

1. Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

2. Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China

3. China National Clinical Research Center for Child Health, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China

4. Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Abstract

(A) Nanobiotics: myristoylation of KR-12, followed by nano-assembly. (B) Penetration: myristoylated KR-12 creates pores for effective penetration. (C) LPS neutralization: positive charge interacts with bacterial LPS for superior efficacy.

Funder

Henan Provincial Science and Technology Research Project

Key Research and Development Program of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D3NR05174A

Reference44 articles.

1. Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome

2. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

3. Thinking Outside the Bug: Molecular Targets and Strategies to Overcome Antibiotic Resistance

4. Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy

5. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tailoring supramolecular antimicrobial peptides: from self-assembled nanoarchitectures to activities;Science China Materials;2024-09-10

2. Origami of KR-12 Designed Antimicrobial Peptides and Their Potential Applications;Antibiotics;2024-08-28

3. LL-37: Structures, Antimicrobial Activity, and Influence on Amyloid-Related Diseases;Biomolecules;2024-03-08