Calyculin: Nature's way of making the sponge-derived cytotoxin-Reference-Cited by-同舟云学术

Calyculin: Nature's way of making the sponge-derived cytotoxin

Published:2016 Issue:6 Volume:33 Page:751-760
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Wakimoto Toshiyuki¹²³⁴,Egami Yoko¹²³⁴,Abe Ikuro⁵⁶⁷⁴

Affiliation:

1. Faculty of Pharmaceutical Sciences

2. Hokkaido University

3. Sapporo 060-0812

4. Japan

5. Graduate School of Pharmaceutical Sciences

6. University of Tokyo

7. Tokyo 113-0033

Abstract

In this highlight, we focus on the recent studies addressing nature's design and biogenesis of calyculin A, a cytotoxic compound isolated from the Japanese marine sponge Discodermia calyx.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00123D

Reference50 articles.

1. Bioactive marine metabolites. Part 16. Calyculin A. A novel antitumor metabolite from the marine sponge Discodermia calyx

2. Calyculins and Related Marine Natural Products as Serine- Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C

3. Isolation of Calyculins, Calyculinamides, and Swinholide H from the New Zealand Deep-Water Marine Sponge Lamellomorpha strongylata

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