The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery-Reference-Cited by-同舟云学术

The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery

Published:2016 Issue:3 Volume:33 Page:372-381
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Barnes Emma C.¹²³⁴⁵,Kumar Rohitesh¹²³⁴,Davis Rohan A.¹²³⁴

Affiliation:

1. Eskitis Institute for Drug Discovery

2. Griffith University

3. Brisbane

4. Australia

5. Leibniz Institute for Natural Product Research and Infection Biology HKI

Abstract

This Highlight examines the use of isolated natural products as scaffolds in the semi-synthesis of drug discovery libraries, and the potential of this rarely used method to contribute to successful natural product library generation strategies.

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00121H

Reference58 articles.

1. Natural products as starting points for the synthesis of complex and diverse compounds

2. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

3. Scaffold diversity of natural products: inspiration for combinatorial library design

4. Scaffold Flatness: Reversing the Trend

5. Design and synthesis of analogues of natural products

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