Taxol-modified collagen scaffold implantation promotes functional recovery after long-distance spinal cord complete transection in canines

Author:

Yin Wen12345,Li Xing67895,Zhao Yannan67895,Tan Jun12345,Wu Shuyu12345,Cao Yudong12345,Li Juan12345,Zhu Hecheng1045,Liu Weidong1112131415,Tang Guihua162345,Meng Li172345,Wang Lei1112131415,Zhu Bin1112131415,Wang Gousiyi12345,Zhong Meizuo1045,Liu Xingdong1045,Xie Dan181219205,Chen Bing67895,Ren Caiping1112131415,Xiao Zhifeng67895,Jiang Xingjun12345,Dai Jianwu67895ORCID

Affiliation:

1. Department of Neurosurgery

2. Xiangya Hospital

3. Central South University (CSU)

4. Changsha

5. China

6. State Key Laboratory of Molecular Developmental Biology

7. Institute of Genetics and Developmental Biology

8. Chinese Academy of Sciences

9. Beijing 100101

10. Changsha Kexin Cancer Hospital

11. Cancer Research Institute

12. Collaborative Innovation Center for Cancer Medicine

13. Key Laboratory for Carcinogenesis of Chinese Ministry of Health

14. School of Basic Medical Science

15. Central South University

16. Department of Clinical Laboratory

17. Department of Radiology

18. State Key Laboratory of Oncology in South China

19. Sun Yat-sen University Cancer Center

20. Guangzhou

Abstract

LOCS + Taxol implantation, a promising treatment for acute spinal cord injury, promotes endogenous neurogenesis, axon regeneration and locomotion recovery.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

Hunan Provincial Science and Technology Department

Central South University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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