Injectable liposome-containing click hydrogel microparticles for release of macromolecular cargos

Author:

Palmese Luisa L1ORCID,LeValley Paige J.2,Pradhan Lina2,Parsons Amanda L.3,Oakey John S.3ORCID,Abraham Mathew4,D’Addio Suzanne M.5,Kloxin April M.12ORCID,Liang Yingkai5ORCID,Kiick Kristi L.16ORCID

Affiliation:

1. Materials Science and Engineering, University of Delaware, Newark, DE, USA

2. Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA

3. Chemical and Biomedical Engineering, University of Wyoming, Laramie, WY, USA

4. Translational Imaging, Merck & Co., Inc., West Point, PA, USA

5. Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, PA, USA

6. Biomedical Engineering, University of Delaware, Newark, DE, USA

Abstract

Microgels with or without chemically crosslinked liposomes (lipo-microgels) were fabricated using microfluidics and Michael-type addition reactions for encapsulation and release of macromolecular cargos.

Funder

National Institute of General Medical Sciences

Merck

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

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