Aggregation propensity of therapeutic fibrin-homing pentapeptides: insights from experiments and molecular dynamics simulations-Reference-Cited by-同舟云学术

Aggregation propensity of therapeutic fibrin-homing pentapeptides: insights from experiments and molecular dynamics simulations

Published:2020 Issue:44 Volume:16 Page:10169-10179
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Zanuy David¹²³⁴^ORCID,Puiggalí-Jou Anna¹²³⁴^ORCID,Conflitti Paolo⁵⁶⁷⁸⁹^ORCID,Bocchinfuso Gianfranco⁵⁶⁷⁸⁹^ORCID,Palleschi Antonio⁵⁶⁷⁸⁹^ORCID,Alemán Carlos¹²³⁴¹⁰^ORCID

Affiliation:

1. Department of Chemical Engineering and Barcelona Research Center in Multiscale Science and Engineering

2. Universitat Polytècnica de Catalunya

3. 08019 Barcelona

4. Spain

5. Dipartimento di Scienze e Tecnologie Chimiche

6. Universitàdi Roma‘‘Tor Vergata’’

7. via della ricerca scientifica 1

8. Rome

9. Italy

10. Institute for Bioengineering of Catalonia (IBEC)

Abstract

CREKA (Cys–Arg–Glu–Lys–Ala) and its engineered analogue CRMeEKA, (N-methyl-Glu instead of Glu), are emerging pentapeptides that were specifically designed to bind fibrin–fibronectin complexes accumulated in the walls of tumour vessels.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Agència de Gestió d’Ajuts Universitaris i de Recerca

Generalitat de Catalunya

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SM/D0SM00930J

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1. Identification of optimal protein binders through the use of large genetically encoded display libraries