Studies on asymmetric total synthesis of (−)-β-hydrastine via a chiral epoxide ring-opening cascade cyclization strategy
Author:
Affiliation:
1. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education
2. Shenyang Pharmaceutical University
3. Shenyang
4. People's Republic of China
5. Wuya College of Innovation
Abstract
Herein, both CF3COOH-catalyzed (86% ee) and KHMDS-catalyzed (78% ee) chiral epoxide ring-opening cascade cyclization to facile and enantioselective synthesis of the core phthalide tetrahydroisoquinoline scaffold of (−)-β-hydrastine are described.
Funder
Ministry of Education of the People's Republic of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03038D
Reference37 articles.
1. The Phthalideisoquinoline Alkaloids
2. Effects of (1R,9S)-.BETA.-Hydrastine on Intracellular Calcium Concentration in PC12 Cells
3. Enantio-selective inhibition of (1R,9S)- and (1S,9R)-β-hydrastines on dopamine biosynthesis in PC12 cells
4. New alkaloids fromCorydalisspecies
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