Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic β-cells-Reference-Cited by-同舟云学术

Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic β-cells

Published:2021 Issue:40 Volume:12 Page:13506-13512
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tobias Janelle M.¹²³^ORCID,Rajic Gabriela¹,Viray Alexander E. G.¹²^ORCID,Icka-Araki David¹²⁴,Frank James A.¹²^ORCID

Affiliation:

1. Vollum Institute, Oregon Health & Science University, Portland, OR, USA

2. Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, OR, USA

3. Graduate Program in Physiology & Pharmacology, Oregon Health & Science University, Portland, OR, USA

4. Graduate Program in Biomedical Sciences, Oregon Health & Science University, Portland, OR, USA

Abstract

Optically-cleavable targeted ligands unite photocaged chemistry with genetic targeting to induce cell activity at defined membranes. OCT-PEA uncaging stiumlates β-cell activity via cell surface GPR55.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02527A

Reference42 articles.

1. Cannabinoids and the expanded endocannabinoid system in neurological disorders

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3. Stimulus-Secretion Coupling in Beta-Cells: From Basic to Bedside

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