Continuous-flow label-free size fractionation of extracellular vesicles through electrothermal fluid rolls and dielectrophoresis synergistically integrated in a microfluidic device-Reference-Cited by-同舟云学术

Continuous-flow label-free size fractionation of extracellular vesicles through electrothermal fluid rolls and dielectrophoresis synergistically integrated in a microfluidic device

Published:2023 Issue:10 Volume:23 Page:2421-2433
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Bu Yang¹,Wang Jinhui²,Ni Sheng¹^ORCID,Guo Yusong²,Yobas Levent¹³^ORCID

Affiliation:

1. Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

2. Division of Life Sciences, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

3. Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, SAR, China

Abstract

Effective separation of small extracellular vesicles (EVs) especially exosomes from large EVs with a high recovery rate and purity based on electrokinetic principles in a microfluidic device featuring three-dimensional silicon microelectrodes.

Funder

Research Grants Council, University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D2LC01193J

Reference58 articles.

1. Extracellular vesicles: Exosomes, microvesicles, and friends

2. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

3. Current methods for the isolation of extracellular vesicles