Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds-Reference-Cited by-同舟云学术

Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds

Published:2020 Issue:68 Volume:10 Page:41802-41806
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Yuewei¹²³⁴^ORCID,Bao Qingqing¹²³⁴,Zhang Ning¹²³⁴,Wang Shuohang¹²³⁴,Yu Xue¹²³⁴

Affiliation:

1. School of Chemistry and Pharmaceutical Engineering

2. Jilin Institute of Chemical Technology

3. Jilin 132022

4. China

Abstract

An efficient and highly diastereoselective synthesis of 2-substituted benzo[b]azepin-5-olviastereocontrolled addition of Grignard reagents to oxa-bridged benzazepines has been developed.

Funder

Education Department of Jilin Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA08758K

Reference48 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide Derivatives

3. d-Fused [1]Benzazepines with Selective in Vitro Antitumor Activity: Synthesis and Structure−Activity Relationships

4. Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety

5. Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

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