Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

Author:

Sohtome Yoshihiro12345ORCID,Shimazu Tadahiro624,Barjau Joaquin1234,Fujishiro Shinya1234,Akakabe Mai1234,Terayama Naoki12345,Dodo Kosuke12345ORCID,Ito Akihiro54784,Yoshida Minoru5491011,Shinkai Yoichi624,Sodeoka Mikiko12345ORCID

Affiliation:

1. Synthetic Organic Chemistry Laboratory

2. RIKEN Cluster for Pioneering Research

3. Saitama 351-0198

4. Japan

5. RIKEN Center for Sustainable Resource Science, RIKEN

6. Cellular Memory Laboratory

7. School of Life Sciences

8. Tokyo University of Pharmacy and Life Sciences

9. Department of Biotechnology

10. Graduate School of Agricultural Life Sciences

11. The University of Tokyo

Abstract

We present a chemical methylome analysis to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases.

Funder

RIKEN

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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