New geldanamycin derivatives with anti Hsp properties by mutasynthesis-Reference-Cited by-同舟云学术

New geldanamycin derivatives with anti Hsp properties by mutasynthesis

Published:2019 Issue:21 Volume:17 Page:5269-5278
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hermane Jekaterina¹²³⁴,Eichner Simone¹²³⁴,Mancuso Lena¹²³⁴,Schröder Benjamin¹²³⁴,Sasse Florenz⁵⁶⁷⁴^ORCID,Zeilinger Carsten²⁸⁹⁴,Kirschning Andreas¹²³⁴^ORCID

Affiliation:

1. Institute of Organic Chemistry

2. Leibniz Universität Hannover

3. 30167 Hannover

4. Germany

5. Helmholtz-Center for Infection Research

6. Department of Microbial Communication

7. 38124 Braunschweig

8. Institute of Biophysics and Center of Biomolecular Drug Research (BMWZ)

9. D-30167 Hannover

Abstract

Four new non hydroquinone derivatives of geldanamycin are prepared by mutasynthesis and their antiproliferative as well as inhibitory properties for human as well as bacterial heatshock proteins are evaluated.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00892F

Reference47 articles.

1. Mutasynthesis of new antibiotics

2. The biosynthesis of antibiotics

3. PREPARATION OF FOUR NEW ANTIBIOTICS FROM A MUTANT OF Streptomyces fradiae

4. Mutational biosynthesis—a tool for the generation of structural diversity in the biosynthesis of antibiotics

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