Ligand-induced action of the W2866.48 rotamer toggle switch in the β2-adrenergic receptor-Reference-Cited by-同舟云学术

Ligand-induced action of the W2866.48 rotamer toggle switch in the β2-adrenergic receptor

Published:2018 Issue:1 Volume:20 Page:581-594
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Plazinska Anita¹²³⁴⁵^ORCID,Plazinski Wojciech⁶⁷⁸⁵^ORCID,Luchowski Rafal⁹¹⁰¹¹¹²⁵,Wnorowski Artur¹²³⁴⁵,Grudzinski Wojciech⁹¹⁰¹¹¹²⁵,Gruszecki Wieslaw I.⁹¹⁰¹¹¹²⁵

Affiliation:

1. Department of Biopharmacy

2. Faculty of Pharmacy

3. Medical University of Lublin

4. 20-093 Lublin

5. Poland

6. J. Haber Institute of Catalysis and Surface Chemistry

7. Polish Academy of Sciences

8. 30-239 Cracow

9. Department of Biophysics

10. Institute of Physics

11. Maria Curie-Sklodowska University

12. 20-031 Lublin

Abstract

The combined molecular dynamics and time-resolved fluorescence spectroscopy study reveals how the pharmacological character of the bound ligand is connected with its influence on the toggle switch of the β₂-adrenergic receptor.

Funder

Narodowe Centrum Badań i Rozwoju

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CP/C7CP04808D

Reference72 articles.

1. High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

2. Structure of a nanobody-stabilized active state of the β2 adrenoceptor