An alternative mode to activate alcohols: application to the synthesis of N-heteroarene derivatives-Reference-Cited by-同舟云学术

An alternative mode to activate alcohols: application to the synthesis of N-heteroarene derivatives

Published:2021 Issue:18 Volume:8 Page:5112-5117
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Liu Xiaoping¹,Sotiropoulos Jean-Marc²,Taillefer Marc¹^ORCID

Affiliation:

1. ICGM, Université de Montpellier, CNRS, ENSCM, 34296 Montpellier, France

2. CNRS, Université de Pau et des Pays de l'Adour, E2S UPPA, IPREM, Pau, France

Abstract

Activation of primary alcohols in the presence of KOtBu/DMF allowed the synthesis of N-heteroarenes via the alkylation of the C(sp3)–H bond of methyl azaarenes. A mechanism involving the formation of an alkyl formate intermediate is proposed.

Funder

Académie des Sciences, Institut de France

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D1QO00930C

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