Multimodal and multifunctional nanoparticles with platelet targeting ability and phase transition efficiency for the molecular imaging and thrombolysis of coronary microthrombi-Reference-Cited by-同舟云学术

Multimodal and multifunctional nanoparticles with platelet targeting ability and phase transition efficiency for the molecular imaging and thrombolysis of coronary microthrombi

Published:2020 Issue:18 Volume:8 Page:5047-5060
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Bai Sheng¹²³⁴^ORCID,Liao Jintang¹²³⁴,Zhang Bo¹²³⁴,Zhao Min⁵²³⁴,You Baiyang⁶⁷²³⁴,Li Pan⁸⁹¹⁰^ORCID,Ran Haitao⁸⁹¹⁰^ORCID,Wang Zhigang⁸⁹¹⁰^ORCID,Shi Ruizheng¹¹²³⁴,Zhang Guogang¹¹²³⁴

Affiliation:

1. Department of Ultrasound

2. Xiangya Hospital Central South University

3. Changsha

4. China

5. Department of Nuclear Medicine

6. Cardiac Rehabilitation Center

7. Department of Rehabilitation

8. Institute of Ultrasound imaging of Chongqing Medical University

9. Chongqing 400010

10. P. R. China

11. Department of Cardiovascular Medicine

Abstract

In this article, we constructed PLGA-cRGD-PFH-ICG NPs through emulsification process and then the bi-modal imaging of coronary microthrombi in ischemia/reperfusion rat model and thrombolysis of clots in vitro were both successfully completed by these NPs.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/D0BM00818D

Reference62 articles.

1. Microvascular Obstruction