Structure–cytotoxicity relationship of drug-initiated polymer prodrug nanoparticles-Reference-Cited by-同舟云学术

Structure–cytotoxicity relationship of drug-initiated polymer prodrug nanoparticles

Published:2017 Issue:34 Volume:8 Page:5174-5184
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Bao Yinyin¹²³⁴⁵,Nicolas Julien¹²³⁴⁵^ORCID

Affiliation:

1. Institut Galien Paris-Sud

2. CNRS UMR 8612

3. Univ Paris-Sud

4. Faculté de Pharmacie

5. 92290 Châtenay-Malabry

Abstract

Cladribine (CdA)-based polymer prodrug nanoparticles were obtained by “drug-initiated” RAFT polymerization of squalenyl methacrylate (SqMA) from two different CdA-bearing chain transfer agents (CTAs) to evaluate the influence of the nature of the linkage between CdA and the CTA, and the bulkiness of the polymer, on the drug release and the biological performance.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2017/PY/C7PY00536A

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