Dual inhibitors of epidermal growth factor receptor and topoisomerase IIα derived from a quinoline scaffold-Reference-Cited by-同舟云学术

Dual inhibitors of epidermal growth factor receptor and topoisomerase IIα derived from a quinoline scaffold

Published:2016 Issue:81 Volume:6 Page:77717-77734
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chauhan Monika¹²³⁴⁵,Joshi Gaurav¹²³⁴⁵,Kler Harveen¹²³⁴⁵,Kashyap Archana¹²³⁴⁵,Amrutkar Suyog M.⁶⁷⁸⁵^ORCID,Sharma Praveen⁹³⁴⁵,Bhilare Kiran D.⁶⁷⁸⁵,Chand Banerjee Uttam⁶⁷⁸⁵,Singh Sandeep⁹³⁴⁵,Kumar Raj¹²³⁴⁵

Affiliation:

1. Laboratory for Drug Design and Synthesis

2. Centre for Pharmaceutical Sciences and Natural Products

3. Central University of Punjab

4. Bathinda

5. India

6. Department of Pharmaceutical Technology (Biotechnology)

7. National Institute of Pharmaceutical Education and Research (NIPER)

8. Mohali

9. Centre for Human Genetics and Molecular Medicine

Abstract

Based on the quinazoline bearing EGFR inhibitors, a series of thirty four compounds having a quinoline scaffold were synthesized and evaluated in vitro for EGFR kinase inhibitory and anticancer activities.

Funder

Science and Engineering Research Board

University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA15118C

Reference44 articles.

1. The protein tyrosine kinase family of the human genome

2. Cell Signaling by Receptor Tyrosine Kinases