A dual-enzyme cleavable linker for antibody–drug conjugates-Reference-Cited by-同舟云学术

A dual-enzyme cleavable linker for antibody–drug conjugates

Published:2021 Issue:28 Volume:57 Page:3457-3460
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bargh Jonathan D.¹²³⁴⁵^ORCID,Walsh Stephen J.¹²³⁴⁵^ORCID,Ashman Nicola¹²³⁴⁵^ORCID,Isidro-Llobet Albert⁶⁷⁸⁵^ORCID,Carroll Jason S.⁹²¹⁰⁴⁵^ORCID,Spring David R.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Lensfield Road

4. Cambridge

5. UK

6. GSK

7. Gunnels Wood Road

8. Stevenage

9. Cancer Research UK Cambridge Institute

10. Robinson Way

Abstract

A 3-O-sulfo-β-galactose linker is cleaved by two lysosomal enzymes to release payloads from ADCs at targeted cancer cells.

Funder

Royal Society

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC00957E

Reference26 articles.

1. Site-selective modification strategies in antibody–drug conjugates

2. Strategies and challenges for the next generation of antibody–drug conjugates

3. Antibody – Drug conjugates (ADC) – Drug discovery today: Technologies

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