Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L-Reference-Cited by-同舟云学术

Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L

Published:2021 Issue:32 Volume:12 Page:10825-10835
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Phan Hoang Anh T.¹^ORCID,Giannakoulias Sam G.¹^ORCID,Barrett Taylor M.¹,Liu Chunxiao¹²,Petersson E. James¹^ORCID

Affiliation:

1. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

2. Key Laboratory for Northern Urban Agriculture of Ministry of Agriculture and Rural Affairs, Beijing University of Agriculture, Beijing 102206, P. R. China

Abstract

Information on the effects of sidechain and backbone modification on the activity of cathepsin (Cts) L, V, K, S, and B was used to design a thioamide peptide that is inert to all Cts and selectively inhibits Cts L.

Funder

University of Pennsylvania

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00785H

Reference79 articles.

1. Peptide therapeutics: current status and future directions