Synthesis and <i>in vitro</i> photodynamic activity of aza-BODIPY-based photosensitizers-Reference-Cited by-同舟云学术

Synthesis and in vitro photodynamic activity of aza-BODIPY-based photosensitizers

Published:2023 Issue:29 Volume:21 Page:6018-6027
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hlogyik Tamás¹,Laczkó-Rigó Réka²^ORCID,Bakos Éva²,Poór Miklós³,Kele Zoltán⁴,Özvegy-Laczka Csilla²,Mernyák Erzsébet¹^ORCID

Affiliation:

1. Department of Inorganic, Organic and Analytical Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary

2. Drug resistance research group, Institute of Enzymology, Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary

3. Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Rókus u. 2, H-7624 Pécs, Hungary

4. Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary

Abstract

New aza-BODIPY derivatives as potential photosensitizers were synthesized. The bis-triazolyl-TEG derivative (14) showed superior phototoxicity against the A431 cell line with an excellent photo-to-dark toxicity ratio acting in the nanomolar range.

Funder

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal

National Research, Development and Innovation Office

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00699A

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