XT-type DNA hydrogels loaded with VEGF and NGF promote peripheral nerve regeneration via a biphasic release profile-Reference-Cited by-同舟云学术

XT-type DNA hydrogels loaded with VEGF and NGF promote peripheral nerve regeneration via a biphasic release profile

Published:2021 Issue:24 Volume:9 Page:8221-8234
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Liu Songyang¹²³^ORCID,Liu Yijun¹²⁴,Zhou Liping⁵^ORCID,Li Ci¹²,Zhang Meng¹²,Zhang Fengshi¹²,Ding Zhentao¹²,Wen Yongqiang⁵^ORCID,Zhang Peixun¹²^ORCID

Affiliation:

1. Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China

2. Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing, China

3. National Center for Trauma Medicine, Beijing, China

4. Department of Foot and Ankle Surgery, Center for Orthopaedic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China

5. Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China

Abstract

Preparation of XT-type DNA hydrogel loaded with VEGF and NGF which could achieve their biphasic release.The repair effect and mechanism of the XT-type DNA hydrogels on a 10 mm peripheral nerve defect were investigated in vitro and in vivo.

Funder

Ministry of Education of the People's Republic of China

Central University Basic Research Fund of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM01377G

Reference33 articles.

1. Scaffolds for peripheral nerve repair and reconstruction