Discovery, synthesis, activities, structure–activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review-Reference-Cited by-同舟云学术

Discovery, synthesis, activities, structure–activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review

Published:2024 Issue: Volume: Page:
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Singh Sheo B.¹²³^ORCID

Affiliation:

1. Charles A Dana Research Institute for Scientists Emeriti (RISE), Drew University, Madison, NJ 07940, USA

2. Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA

3. SBS Pharma Consulting LLC, Edison, NJ 08820, USA

Abstract

This comprehensive review describes discovery, synthesis, structure activity relationship, and anticancer activity of six series of 22 natural products as well as clinical studies of several candidates.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NP/D3NP00053B

Reference142 articles.

1. Isolation and structure of combretastatin

2. Antineoplastic Agents, 122. Constituents of Combretum caffrum

3. Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum

4. Isolation, structure, and synthesis of combretastatin A-2, A-3, and B-2

5. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

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