One-step, kit-based radiopharmaceuticals for molecular SPECT imaging: a versatile diphosphine chelator for 99mTc radiolabelling of peptides-Reference-Cited by-同舟云学术

One-step, kit-based radiopharmaceuticals for molecular SPECT imaging: a versatile diphosphine chelator for 99mTc radiolabelling of peptides

Published:2021 Issue:44 Volume:50 Page:16156-16165
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Hungnes Ingebjørg N.¹,Al-Salemee Fahad¹^ORCID,Gawne Peter J.¹^ORCID,Eykyn Thomas¹,Atkinson R. Andrew²³,Terry Samantha Y. A.¹,Clarke Fiona⁴,Blower Philip J.¹^ORCID,Pringle Paul G.⁵^ORCID,Ma Michelle T.¹^ORCID

Affiliation:

1. King's College London, School of Biomedical Engineering and Imaging Sciences, 4th Floor Lambeth Wing, St Thomas’ Hospital, London, UK

2. King's College London, Randall Centre for Cell and Molecular Biophysics, and Centre for Biomolecular Spectroscopy, London, UK

3. Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077 Toulouse, France

4. King's College London, Centre for Inflammation Biology and Cancer Immunology, Faculty of Life Sciences and Medicine, London, UK

5. University of Bristol, School of Chemistry, Cantock's Close, Bristol, UK

Abstract

We report a versatile diphosphine platform for 99mTc radiolabelling of peptides. The diphosphine-peptide conjugate can be radiolabelled with 99mTc in a single step, and the new radiotracer is capable of receptor-targeted imaging of disease in vivo.

Funder

Cancer Research UK

Rosetrees Trust

Wellcome

Engineering and Physical Sciences Research Council

British Heart Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT03177E