Highly enantioselective desymmetrization of prochiral cyclic α,α-dicyanoalkenes via the direct vinylogous Michael/cyclization domino reaction-Reference-Cited by-同舟云学术

Highly enantioselective desymmetrization of prochiral cyclic α,α-dicyanoalkenes via the direct vinylogous Michael/cyclization domino reaction

Published:2018 Issue:16 Volume:5 Page:2505-2509
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Mei Hongjiang¹²³⁴⁵^ORCID,Lin Lili¹²³⁴⁵^ORCID,Shen Bin¹²³⁴⁵^ORCID,Liu Xiaohua¹²³⁴⁵^ORCID,Feng Xiaoming¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Green Chemistry & Technology

2. Ministry of Education

3. College of Chemistry

4. Sichuan University

5. Chengdu 610064

Abstract

A chiral N,N′-dioxide/Mg(ii) complex efficiently constructs spiroindolinones which include three adjacent atom chiralities and a tertiary carbon center at remote sites in up to 95% yield, with 99% ee and 20 : 1 dr.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00545A

Reference41 articles.

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2. Enantioselective desymmetrisation

3. Asymmetric Alcoholysis of Cyclic Anhydrides

4. Recent progress on asymmetric organocatalytic construction of chiral cyclohexenone skeletons

5. Organocatalytic enantioselective desymmetrisation

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