Novel tetrahydropyrimidinyl-substituted benzimidazoles and benzothiazoles: synthesis, antibacterial activity, DNA interactions and ADME profiling-Reference-Cited by-同舟云学术

Novel tetrahydropyrimidinyl-substituted benzimidazoles and benzothiazoles: synthesis, antibacterial activity, DNA interactions and ADME profiling

Published:2022 Issue:12 Volume:13 Page:1504-1525
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Rep Valentina¹^ORCID,Štulić Rebeka¹,Koštrun Sanja²,Kuridža Bojan³,Crnolatac Ivo³,Radić Stojković Marijana³^ORCID,Paljetak Hana Čipčić⁴,Perić Mihaela⁴,Matijašić Mario⁴,Raić-Malić Silvana¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia

2. Selvita d.o.o, Prilaz baruna Filipovića 29, 10000 Zagreb, Croatia

3. Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička cesta 54, 10000 Zagreb, Croatia

4. Department for Intercellular Communication, Center for Translational and Clinical Research, University of Zagreb School of Medicine, Šalata 2, 10000 Zagreb, Croatia

Abstract

The most active benzimidazole 15a against E. coli, M. catarrhalis and both sensitive and resistant strains of S. pyogenes showed preference toward AT-rich sites and minor groove binding mode, which was in line with docking studies.

Funder

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00143H

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1. A Review on Antibiotic Resistance: Alarm Bells are Ringing

2. Antibiotic resistance: a rundown of a global crisis

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