In silico investigation of the selectivity mechanism of A1AR and A2AAR antagonism-Reference-Cited by-同舟云学术

In silico investigation of the selectivity mechanism of A₁AR and A_2AAR antagonism

Published:2022 Issue:43 Volume:46 Page:20643-20657
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Li Weixia¹²³^ORCID,Hu Baichun¹²⁴^ORCID,Liu Haihan¹²³,Luan Jiasi¹²⁵^ORCID,Chen Lu¹²³^ORCID,Wang Shizun¹²³^ORCID,Fan Liye¹²³,Wang Jian¹²³^ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drug Design &Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

2. Key Laboratory of Intelligent Drug Design and New Drug Discovery of Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, China

3. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

4. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

5. School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

Abstract

Adenosine A1 receptor (A1AR) and adenosine A2A receptor (A2AAR) are AR isoforms that share high homology but play many different roles in terms of regulating arteriolar pressure and urine flow as well as relieving neurodegenerative disorders.

Funder

Scientific Research Fund of Liaoning Provincial Education Department

Overseas Expertise Introduction Project for Discipline Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ03536G

Reference30 articles.

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