Tandem addition/cyclization for synthesis of 2-aroyl benzofurans and 2-aroyl indoles by carbopalladation of nitriles

Author:

Gong Julin1234,Hu Kun1234,Shao Yinlin1234,Li Renhao5674,Zhang Yetong1234,Hu Maolin1234,Chen Jiuxi1234ORCID

Affiliation:

1. College of Chemistry & Materials Engineering

2. Wenzhou University

3. Wenzhou 325035

4. P. R. China

5. School of Pharmaceutical Sciences

6. Wenzhou Medical University

7. Wenzhou

Abstract

Pd-Catalyzed tandem reaction of 2-(2-acylphenoxy)acetonitriles or 2-((2-benzoylphenyl)amino)acetonitrile with arylboronic acids for the synthesis of 2-aroyl benzofurans and 2-aroyl indoles.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference64 articles.

1. Nitrile Ligated Transition Metal Complexes with Weakly Coordinating Counteranions and Their Catalytic Applications

2. Additions to Metal-Activated Organonitriles

3. Some recent applications of α-amino nitrile chemistry

4. Z. Rappoport , The Chemistry of the Cyano Group , Wiley , London , 1970

5. R. C. Larock , Comprehensive Organic Transformations: A Guide to Functional Group Preparations , VCH , New York , 1989

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