Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling

Author:

Zhao Shan12345,Dai Jianye12345,Hu Mo67873,Liu Chang67873,Meng Rong67873,Liu Xiaoyun67873,Wang Chu12345,Luo Tuoping12345

Affiliation:

1. Peking-Tsinghua Center for Life Sciences

2. Academy for Advanced Interdisciplinary Studies

3. Peking University

4. Beijing 100871

5. China

6. Beijing National Laboratory for Molecular Science (BNLMS)

7. College of Chemistry and Molecular Engineering

8. Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education

Abstract

The coupling reactions of diaryltetrazoles with carboxylic acids under UV irradiation were investigated. Application of these transformations in chemical biology was demonstrated in photo-labelling the proteinogenic carboxylic acids in purified proteins, cell lysates and living cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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