Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication-Reference-Cited by-同舟云学术

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication

Published:2023 Issue:26 Volume:13 Page:17667-17677
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bajaj Teena¹^ORCID,Wehri Eddie²,Suryawanshi Rahul K.³,King Elizabeth⁴^ORCID,Pardeshi Kundan Singh⁵^ORCID,Behrouzi Kamyar⁶,Khodabakhshi Zahra⁵,Schulze-Gahmen Ursula³,Kumar G. Renuka³,Mofrad Mohammad R. K.⁵^ORCID,Nomura Daniel K.⁷^ORCID,Ott Melanie³⁸⁹,Schaletzky Julia²,Murthy Niren⁵^ORCID

Affiliation:

1. Graduate Program of Comparative Biochemistry, University of California, Berkeley, CA, USA

2. The Henry Wheeler Center of Emerging and Neglected Diseases, 344 Li Ka Shing, Berkeley, CA, USA

3. Gladstone Institute of Virology Gladstone Institutes, San Francisco, CA, USA

4. Chemical Biology Graduate Program, University of California, Berkeley, CA, USA

5. Department of Bioengineering, University of California, Berkeley, CA, USA

6. Department of Mechanical Engineering, University of California, Berkeley, CA, USA

7. Department of Chemistry, University of California, Berkeley, CA, USA

8. Department of Medicine, University of California, San Francisco, CA, USA

9. Chan Zuckerberg Biohub, San Francisco, CA, USA

Abstract

Screening of the ChemDiv library against PLpro, an essential protein from the SCoV-2 virus, identified compound 5. Compound 5 is a reversible covalent inhibitor of PLpro and prevents SCoV-2 infection in cells.

Funder

Gladstone Institutes

Innovative Genomics Institute

Cystic Fibrosis Foundation

Roddenberry Foundation

James B. Pendleton Charitable Trust

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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