Electron induced single strand break and cyclization: a DFT study on the radiosensitization mechanism of the nucleotide of 8-bromoguanine-Reference-Cited by-同舟云学术

Electron induced single strand break and cyclization: a DFT study on the radiosensitization mechanism of the nucleotide of 8-bromoguanine

Published:2014 Issue:14 Volume:16 Page:6568-6574
ISSN:1463-9076
Container-title:Phys. Chem. Chem. Phys.
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Chomicz Lidia¹²³,Furmanchuk Al'ona⁴⁵⁶,Leszczynski Jerzy⁴⁵⁶,Rak Janusz¹²³

Affiliation:

1. Department of Chemistry

2. University of Gdańsk

3. 80-308 Gdańsk, Poland

4. Interdisciplinary Nanotoxicity Center

5. Jackson State University

6. Jackson, USA

Abstract

The radiosensitization mechanism of 8-bromoguanosine is studied on its 3′,5′-diphosphate. Electron attachment to the nucleotide results in phosphodiester bond breakage or the 5′,8-cycloguanosine lesion.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CP/C3CP55411B

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