A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation-Reference-Cited by-同舟云学术

A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation

Published:2015 Issue:8 Volume:6 Page:4537-4549
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zamudio-Vázquez Rubí¹²³⁴⁵,Ivanova Saška¹²³⁶⁷,Moreno Miguel¹²³,Hernandez-Alvarez Maria Isabel¹²³⁶⁷,Giralt Ernest¹²³⁸⁹,Bidon-Chanal Axel¹⁰¹¹¹²¹³³,Zorzano Antonio¹²³⁶⁷,Albericio Fernando¹²³⁴⁵,Tulla-Puche Judit¹²³⁴⁵^ORCID

Affiliation:

1. Institute for Research in Biomedicine

2. 08028 Barcelona

3. Spain

4. CIBER-BBN

5. Networking Centre on Bioengineering

6. Department of Biochemistry and Molecular Biology

7. Faculty of Biology

8. Department of Organic Chemistry

9. Faculty of Chemistry

10. Department of Physical Chemistry and Institute of Biomedicine (IBUB)

11. Faculty of Pharmacy

12. University of Barcelona

13. Santa Coloma de Gramenet

Abstract

The most cytotoxic compound from a library of quinoxaline-containing peptides is endocyted into HeLa cells, accumulates in acidic compartments, and blocks autophagy by altering lysosomal function, leading to apoptosis activation.

Funder

Agència de Gestió d'Ajuts Universitaris i de Recerca

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC00125K

Reference62 articles.

1. World Health Organization, Cancer mortality and morbidity, 2013, http://www.who.int/gho/ncd/mortality_morbidity/cancer/en/

2. Hallmarks of Cancer: The Next Generation