Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis-Reference-Cited by-同舟云学术

Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis

Published:2020 Issue:8 Volume:37 Page:1065-1079
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Zwick Christian R.¹²³,Renata Hans¹²³^ORCID

Affiliation:

1. The Scripps Research Institute

2. Jupiter

3. USA

Abstract

This review highlights recent chemoenzymatic syntheses of natural products that feature strategic applications of oxidative transformations with Fe/αKG enzymes.

Funder

National Institute of General Medical Sciences

Scripps Research Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NP/C9NP00075E

Reference124 articles.

1. R. P. Hausinger , in 2-Oxoglutarate-Dependent Oxygenases , ed. R. P. Hausinger and C. J. Schofield , The Royal Society of Chemistry, Thomas Graham House , Science Park, Milton Road, Cambridge CB4 0WF, UK , 2015 , vol. 1 , pp. 1–58

2. Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes

3. Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

4. Characteristics and biotechnology applications of aliphatic amino acid hydroxylases belonging to the Fe(II)/α-ketoglutarate-dependent dioxygenase superfamily

5. Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

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