New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies-Reference-Cited by-同舟云学术

New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies

Published:2021 Issue:58 Volume:11 Page:36989-37010
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Syam Yasmin M.¹,Anwar Manal M.¹^ORCID,Abd El-Karim Somaia S.¹^ORCID,Elseginy Samia A.²,Essa Basma M.³^ORCID,Sakr Tamer M.³

Affiliation:

1. Department of Therapeutic Chemistry, National Research Center, Dokki, Cairo 12622, Egypt

2. Green Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt

3. Radioactive Isotopes and Generator Department, Hot Laboratories Centre, Egyptian Atomic Energy Authority (EAEA), P.O. Box 13759, Cairo, Egypt

Abstract

The current work represents the design and synthetic approaches of a new set of compounds 6–10 bearing the 1,4-dimethyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide scaffold.

Funder

Academy of Scientific Research and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA06799K

Reference81 articles.

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3. Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors

4. Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the treatment of type 2 diabetes mellitus

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